CONTROLLED RELEASE OF CD200 INHIBITS INFLAMMATORY MACROPHAGES AND CHONDROCYTE CATABOLISM

Purpose: In post-traumatic osteoarthritis (PTOA), inflammation plays a central role in which macrophages the synovium are classically activated to M1-like state and secrete pro-inflammatory cytokines. The ensuing chronic loop of self-perpetuating tissue damage macrophage activation ultimately exacerbates cartilage degradation joint degeneration. When polarized an anti-inflammatory M2-like phenotype, they can trigger immunosuppressive response within joint.